He married Elizabeth Mary Plummer in 1859. Their children were Lillie P. Bliss (1864-1931), one of the founders of the Museum of Modern Art in New York, and of the financier Cornelius Newton Bliss Jr. (1875-1949).
He was a successful merchant (Bliss, Fabyan & Co. , wholesale dry-goods merchants), politician (Secretary of the Interior in the administration of President William McKinley) and art collector. He bought Brown and Silver: Old Battersea Bridge y033 and presented it to the Addison Gallery of American Art in 1928.
The Frick Collection, Archives Directory for the History of Collecting in America, The Frick Collection.
'Cornelius Newton Bliss', Wikipedia.