She married Demas Barnes in Saint Louis in 1878, and they moved to New York. They had one child, Mildred Barnes-Bliss, born on 9 September 1879. After the death of Demas Barnes in 1888, she married William Henry Bliss on 14 April 1894.
She was a wealthy philanthropist and collector. She owned Nocturne in Blue and Silver: The Lagoon,Venice y212.
'Anna Barnes Bliss (1851–1935)', Dunbarton Oaks website.