Sophia Manuel, née Ionides, was the sister of Nellie Whistler. She married Miltiades Basil Manuel (1841-1907). They had a son, Stephen Manuel.
Whistler seemed to be very fond of Sophie Manuel, whom he described as 'delightful' [#06713]. She commissioned Whistler to paint her son's portrait. Sittings for Arrangement in Grey: Portrait of Master Stephen Manuel y321 took place in 1885. According to the artist Walter Sickert, Whistler did not work quickly enough for the child who became tired from posing. Sickert made an etched portrait of him at the same time.
Young, Andrew McLaren, Margaret F. MacDonald, Robin Spencer, and Hamish Miles, The Paintings of James McNeill Whistler, New Haven and London, 1980 .